The below mentioned article provides a short note on the Disorders of Plasma Membranes. Mutations affecting the protein constituents of membranes can cause many diseases. Proteins in membranes are classified as receptors, transporters, ion channels, enzymes, and structural components. All these classes are often glycosylated, so that mutations affecting this process may change their function. […]
Disorders of Plasma Membranes | Biochemistry
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Diseases due to Abnormalities in Synthesis of Glycoproteins
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The following points highlight the seven major diseases caused due to abnormalities in the synthesis of glycoproteins. 1. Many cancer cells exhibit different profiles of oligosaccharide chains on their surfaces and some of which contribute to metastasis. 2. Carbohydrate-deficient glycoprotein syndrome (CDGS) is caused due to defects in the biosynthesis of N-glycan chains (e.g., due […]
Processes which Requires Involvement of Glycoproteins
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The following points highlight the two main processes which requires involvement of glycoproteins. The processes are: 1. Importance of Glycoproteins in Fertilization 2. Selectins Play Key Roles in Inflammation. Process # 1. Importance of Glycoproteins in Fertilization: (a) A sperm has to traverse the Zona Pellucida (ZP), a thick, transparent, non-cellular envelope that surrounds the […]
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