The following point highlight the five main types of structural variation in chromosomes. The types are: 1. Deletion or Deficiency 2. Duplications 3. Translocations 4. Inversions 5. B-Chromosomes. Type # 1. Deletion or Deficiency: A deficiency means deletion of a small portion of a chromosome resulting in loss of one or more genes. A deficiency originates from breakage occurring at [...]
In this article we will discuss about the interchanges involving more than two pairs of chromosomes. When 3 or more pairs of non-homologous chromosomes are involved in translocation, it is called a complex translocation, complex interchange or multiple translocation. In a single cell, two or more independent heterozygous interchanges show two or more quadruples at MI. Such interchanges are obtained [...]
In this article we will discuss about the translocation in humans. Interchanges are the most common structural chromosome changes reported in human. Partial sterility in interchange heterozygotes is infrequent due to the production of balanced gametes and as a result, interchanges in human are identifiable only through the analysis of karyotype, usually coupled with chromosome banding patterns. Various kinds of [...]