In this article we will discuss about the formation of purine and pyrimidine deoxyribonucleosies. Formation of Purine Deoxyribonucleosides-5′- Triphosphates: The deoxyribonucleotides are simply formed by reduction of the corresponding ribonucleotides. Thus reduction of carbon 2′ of ribose, takes place in E.coli and animal tissues at the ribonucleosides-5′-diphosphates stage, at the cost of a protein of […]
Purine and Pyrimidine Deoxyribonucleosides | Biochemistry
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Biosynthesis of Nucleic Acids | Biochemistry
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In this article we will discuss about the process of biosynthesis of nucleic acids. Biosynthesis of Nucleosides-5′-Triphosphates: Among animals, some amino acids cannot be synthesized and must therefore be supplied through diet (essential amino acids). On the contrary, purine and pyrimidine nucleotides can be synthesized “de novo”, from precursors like CO2, NH3, formiate, glycine etc., […]
Fidelity of the Replication of DNA | Biochemistry
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In this article we will discuss about the fidelity of the replication of DNA. The DNA being the carrier of genetic information it is essential that this information remains correct. But the DNA can be damaged by the action of chemical or physical agents. The cell therefore possesses repair systems which can maintain the integrity […]
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