Kinetic 'order' is a term which simply means that the various processes are ranked in order of increasing complexity. The important kinetic processes which are concerned are those governing the entry of the drug into the blood, its distribution in body tissues, and its elimination from the blood by metabolism and excretion. Such processes are generally of 'zero-order' or 'first-order'. [...]
The plasma level time curve is plotted after measured drug concentration in plasma of an animal at different time intervals. The concentrations of drug in each plasma sample are plotted on an ordinary graph paper against the corresponding time at which the plasma samples were collected. As the drug reaches in systemic circulation, plasma drug concentration will rise to a [...]
This article throws light upon the three main types of pharmacokinetic variables of drugs. The variables are: 1. Plasma Half-Life (t1/2β) 2. Volumes of Distribution 3. Total Body Clearance (CIB). Type # 1. Plasma Half-Life (t1/2β): Half-life is defined as the time of declining the initial plasma drug concentration by half. It is also known as the half-time of elimination [...]