The behavioural tests have been used frequently in pharmacological evaluations of drugs for several years. These tests have only recently been recognized as an essential part of toxicity screening because of belief that behavioural responses of animals have been selected as a measure of toxicity of xenobiotics because of the following reasons: (i) The behaviour of the animals is the [...]
The following points highlight the three main functional tests conducted on animals. The tests are: 1. Respiratory Functional Tests 2. Kidney Functional Tests 3. Assessment of Liver by Liver Functional Test. 1. Respiratory Functional Tests: Tests on these functions are often carried out because of their greater sensitivity than morphological changes and also because of their ability to detect reversible [...]
In this article we will discuss about:- 1. Causes of Teratogenicity 2. Stage Sensitivity for Teratogenicity 3. Mode of Action of Teratogens 4. Administration of Teratogenic Agent 5. Evaluation of Teratogenic Effects. Causes of Teratogenicity: The toxicants which cause teratogenesis are known as teratogenic agents. A gestating-embryo exhibits great dynamicity of the living cells. The embryonic cells multiply and differentiate [...]