The upcoming discussion will update you about the differences between Lock-Key Theory and Induced Fit Theory.
Difference # Lock-Key Theory:
1. Active site is a single entity.
2. There is no separate catalytic group.
3. Active site is static.
4. Development of transition state is not considered.
5. It does not visualize the weakening of substrate bonds.
6. It does not explain the mechanism of non- activity in case of competitive inhibitor.
Difference # Induced Fit Theory:
1. Active site is made of two components.
2. A separate catalytic group is visualized.
3. In contact with substratum, the buttressing group undergoes conformational change.
4. It considers the development of transition state before the reactants undergo change.
5. Catalytic group is believed to weaken the substrate bonds by nucleophile and electrophilic attack.
6. It gives a mechanism for non-action over competitive inhibitor.